久久综合久久鬼色,妺妺跟我一起洗澡没忍住,蜜芽796.coo永不失联,粉嫩虎白扒开视频毛女片

當(dāng)前位置:首頁  >  技術(shù)文章  >  系統(tǒng)性紅斑狼瘡的發(fā)病觸發(fā)髓核細(xì)胞熱下垂,加劇椎間盤退變

系統(tǒng)性紅斑狼瘡的發(fā)病觸發(fā)髓核細(xì)胞熱下垂,加劇椎間盤退變

更新時間:2025-01-23  |  點擊率:244

202410月,浙江中醫(yī)藥大學(xué)第一附屬醫(yī)院(浙江省中醫(yī)醫(yī)院)骨科創(chuàng)傷研究所;杭州富陽中醫(yī)骨科創(chuàng)傷醫(yī)院;浙江中醫(yī)藥大學(xué)第一附屬醫(yī)院(浙江省中醫(yī)醫(yī)院)骨科;浙江中醫(yī)藥大學(xué)基礎(chǔ)醫(yī)學(xué)院 (Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310053, Peoples Republic of China;  Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, Hangzhou, Zhejiang, 311400, Peoples Republic of China;  Department of Orthopaedics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310053, Peoples Republic of China;College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, Peoples Republic of China) Hongting Jin老師研究團(tuán)隊在《Journal of Inflammation Research》上發(fā)表論文:

The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration"

 

“系統(tǒng)性紅斑狼瘡的發(fā)病觸發(fā)髓核細(xì)胞熱下垂,加劇椎間盤退變"

 

Abstract

Purpose

Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by immune system dysregulation and autoantibodies production, causing widespread inflammation and damage across various body systems. Despite the prevalent back pain in SLE patients, the link between SLE and intervertebral disc (IVD) degeneration, a primary contributor to back pain, remains inadequately understood. This study explored the impact of SLE on IVD degeneration using the MRL/lpr mouse model, which effectively replicates human SLE manifestations.

 

Methods

The study utilized MRL/lpr mice to investigate the effects of SLE on IVD degeneration. The mice were evaluated for typical SLE phenotypes and indicators of IVD degeneration, including IVD height, IVD score, tissue integrity, extracellular matrix degradation, and apoptosis of IVD cells. Additionally, the study examined nucleus pulposus (NP) pyroptosis and inflammatory cytokine secretion. Mechanistic analysis focused on the antioxidant pathway, specifically the expression levels of NRF2, HO-1, KEAP1, and the phosphorylation levels of p65.

 

Results

MRL/lpr mice displayed typical SLE phenotypes and exacerbated profiles of IVD degeneration, including reduced IVD height, lower IVD score, significant IVD tissue impairment, extracellular matrix degradation, and increased apoptosis of IVD cells. Notably, SLE stimulated NP pyroptosis and excessive secretion of inflammatory cytokines. Mechanistic analysis indicated that the progression of SLE impedes the antioxidant pathway by downregulating NRF2 and HO-1 expression, upregulating KEAP1, and enhancing phosphorylation levels of p65.

 

Conclusion

Our findings highlight the mechanistic link between SLE and IVD degeneration, suggesting potential therapeutic targets for mitigating back pain in SLE patients.


摘要:

目的:

 

系統(tǒng)性紅斑狼瘡(SLE)是一種以免疫系統(tǒng)失調(diào)和自身抗體產(chǎn)生為特征的自身免疫性疾病,可引起全身各系統(tǒng)的廣泛炎癥和損傷。盡管SLE患者普遍存在背痛,但SLE與椎間盤退變(IVD)之間的聯(lián)系仍未充分了解,椎間盤退變是背痛的主要原因。本研究通過MRL/lpr小鼠模型探索SLEIVD變性的影響,該模型有效地復(fù)制了人類SLE的表現(xiàn)。

 

方法:

本研究利用MRL/lpr小鼠研究SLEIVD變性的影響。評估小鼠的典型SLE表型和IVD變性指標(biāo),包括IVD高度、IVD評分、組織完整性、細(xì)胞外基質(zhì)降解和IVD細(xì)胞凋亡。此外,研究還檢測了髓核(NP)焦亡和炎癥細(xì)胞因子分泌。機(jī)制分析側(cè)重于抗氧化途徑,特別是NRF2、HO-1、KEAP1的表達(dá)水平和p65的磷酸化水平。

 

結(jié)果:

MRL/lpr小鼠表現(xiàn)出典型的SLE表型,IVD退化加劇,包括IVD高度降低、IVD評分降低、IVD組織損傷明顯、細(xì)胞外基質(zhì)降解和IVD細(xì)胞凋亡增加。值得注意的是,SLE刺激NP焦亡和炎性細(xì)胞因子的過量分泌。機(jī)制分析表明,SLE的進(jìn)展通過下調(diào)NRF2HO-1的表達(dá),上調(diào)KEAP1,提高p65的磷酸化水平,從而阻礙了抗氧化途徑。

 

結(jié)論:

我們的研究結(jié)果強(qiáng)調(diào)了SLEIVD變性之間的機(jī)制聯(lián)系,提出了緩解SLE患者背痛的潛在治療靶點。

 

該論文中,Rat NP cell line (rNPCs)的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。



久久久性色精品国产免费观看| 成人性生交a片免费直播软件| 末成年女a片一区二区| 久久久久国產麻豆无碼av| 亚洲av无码一区二区三区观看| 熟妇人妻av无码一区二区三区| 解开人妻的裙子猛烈进入| 日产乱码一二三区别免费| 女人下边水润紧致好处| 再深点灬舒服灬太大了下载| 青青草視頻國產av劇情超爽系列 | 欧美性猛交xxxx免费看| aa片在线观看视频在线播放| 全彩调教本子h里番全彩无码| 国产精品久久久久久久9999| 漂亮人妻洗澡被公强 日日躁 | 国产在视频线精品视频| 军人的粗大(h)拔不出来| 亚洲∧v久久久无码精品| 99精品国产在热2019| 无码少妇一区二区| 国产无套内谢普通话对白| 播放男人添女人下边视频| 精品人妻中文无码av在线| 免费网站安全软件大全| 陪读真实性经历1-13| 我和丰满岳疯狂做爰| 冲田杏梨在线观看| 国模冰冰02[150p]色综合| 仙踪林国精产品视频| 在线亚洲人成电影网站色www| 人妻少妇久久中文字幕| 被黑人扒开双腿猛进| 夜间十八款禁用软件app下载| 午夜18禁试看120秒男女啪啪| 女性全捰艺术照摄影| av鲁丝一区鲁丝二区鲁丝三区| 三个老头捆着躁我一个| 久久精品无码一区二区日韩av| 久久精品国产亚洲av无码偷窥| 婷婷丁香五月|